The drug regulator in India has just approved two breakthrough drugs for the treatment of obesity and type 2 diabetes. According to the claims, the drugs tirzepatide, sold as Mounjaro and Zepbound, developed by pharmaceutical giant Eli Lilly, have returned very outstanding results in clinical trials, giving hope to millions of Indians who suffer from these health issues.
It is a dual GIP/GLP-1 receptor agonist approved by the Central Drugs Standard Control Organisation, an organization whose nod has marked a new chapter in the country’s fight against obesity and diabetes. Its mechanism of action mimics naturally occurring human hormones that stimulate the release of insulin from the pancreas thereby lowering blood sugar levels.
How does Tirzepatide work?
The mechanism of action for tirzepatide includes stimulation of insulin release from the pancreas in a meal-stimulated response, thereby lowering blood sugar levels after eating. Moreover, it is known to reduce the amount of glucagon released. The net result is a reduction in glucose production by the liver.
Further, it delays gastric emptying, which reduces the rate at which glucose from a meal enters the circulation, potentially delaying postprandial blood sugar spikes. By centrally acting through the appetite in the brain, tirzepatide is associated with a decrease in hunger, with a consequent reduction in food intake, leading to weight loss.


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